| 10 September, Monday | |
| Location: Hotel Grand Spa Lietuva, Nemunas Hall | |
| Registration desk | 11:00 - 18:30 |
| Lunch, Hotel restaurant | 12:30 - 14:00 |
| Session 1, chair: Ludmilla Morozova-Roche | |
| Invited talk – Aurora Martinez – Pharmacological chaperones reduce misfolding and pathogenic aggregation in inborn error of metabolism and cancer syndromes | 14:00 - 14:30 |
| Emanuele Celauro – CRISPR-mediated genome editing of TDP-43 in SHSY5Y cells to model ALS | 14:30 - 14:50 |
| Line Christensen – Looking for functional amyloids in the gut of a Parkinson’s disease rat model | 14:50 - 15:10 |
| Christofer Lendel – On the role of peptide hydrolysis for fibrillation kinetics and amyloid fibril morphology | 15:10 - 15:30 |
| Coffee Break | 15:30 - 16:00 |
| Session 2, chair: Christofer Lendel | |
| Médoune Sarr – A spidroin-derived solubility tag enables controlled aggregation of a designed amyloid protein | 16:00 - 16:20 |
| Robert Dec – Extremely potent amyloidogenic properties of a bovine insulin fragment | 16:20 - 16:40 |
| Per Nilsson – Somatostatin receptor subtypes 1 and 4 redundantly regulate the major Aβ-degrading enzyme neprilysin | 16:40 - 17:00 |
| Tanja Weiffert – Increased primary and secondary nucleation rates underlie accelerated aggregation kinetics of N-terminally truncated Aβ5-42 | 17:00 - 17:20 |
| Gefei Chen – A Bri2 BRICHOS mutant specifically interferes with the secondary pathway of Aβ42 fibril formation | 17:20 - 17:40 |
| Igor Iashchishyn – Model of S100A9 Amyloid Formation: Protein Misfolding as “Nucleation” Event | 17:40 - 18:00 |
| Dinner, Hotel restaurant | 19:30 - |
| 11 September, Tuesday | |
| Location: Hotel Grand Spa Lietuva, Nemunas Hall | |
| Session 1, chair: Gunilla Westermark | |
| Invited talk – Stefan Schönland - Systemic amyloidosis – from protein sequence to clinical characterization | 9:00 - 9:30 |
| Vilmantė Borutaitė – Neurotoxic effects of extracellular tau protein | 9:30 - 9:50 |
| Oxana Klementieva – Label-free spectroscopic imaging of primary neurons from transgenic mouse models of Alzheimer´s Disease | 9:50 - 10:10 |
| Tina Arndt – Revealing the unfolding mechanism of the spidroin C-terminal domain | 10:10 - 10:30 |
| Coffee Break | 10:30 - 11:00 |
| Session 2, chair: Kristaps Jaudzems | |
| Andreas Barth – Amyloid β-peptides 1-40 and 1-42 form oligomers with mixed β-sheets according to experimental and computational isotope-edited infrared spectroscopy | 11:00 - 11:30 |
| Oleg Antzutkin – Solid-state NMR insights into structure of a new type of Alzheimer’s Aβ(1-40) aggregates formed when co-incubated with copper ions | 11:30 - 11:50 |
| Xueying Zhong – Structural determination of the Bri2 BRICHOS domain: relevance to Alzheimer’s disease | 11:50 - 12:10 |
| Philip Williamson - Unravelling the Role of S100A9 in the Development of Neurodegenerative Disease | 12:10 - 12:30 |
| Lunch, Hotel restaurant | 12:30 - 14:00 |
| Session 3, chair: Jan Johansson | |
| Per Hammarström – Metamorphic Aβ aggregates | 14:00 - 14:30 |
| Axel Leppert – The Bri2 BRICHOS assembly and activity is regulated by redox conditions | 14:30 - 14:50 |
| Oxana Galzitskaya – Should the treatment of amyloidosis be personified? | 14:50 - 15:10 |
| Flash poster presentations Cesare Baronio - Internal structure of amyloid beta peptide oligomers Tony Werner - Abundant fish protein inhibits α-synuclein amyloid formation | 15:10 - 15:30 |
| Poster Session and Coffee Break | 15:30 - 17:00 |
| Session 4, chair: Sofie Nyström | |
| Ann Tiiman – Detection of amyloidogenic nanoplaques using methods with single-molecule sensitivity | 17:00 - 17:30 |
| Jonathan Pansieri – First mass and charge determination of entire amyloid co-aggregates populations involved in neurodegenerative diseases | 17:30 - 17:50 |
| Rima Budvytytė – Interaction of tethered bilayer membranes with β-amyloid and s100a9 aggregates | 18:50 - 18:10 |
| Cecilia Wallin – The Tau Protein Blocks in Vitro Fibrillation of the Amyloid-β (Aβ) Peptide | 18:10 - 18:30 |
| Dinner, Hotel restaurant | 19:30 - |
| 12 September, Wednesday | |
| Location: Hotel Grand Spa Lietuva, Nemunas Hall | |
| Welcome address - Vytautas Smirnovas & Silvio Tosatto | 8:50 - 9:00 |
| Session 1, chair: Vytautas Smirnovas | |
| Invited talk - Ronald Melki - Prion-like propagation of alpha-synuclein protein assemblies in Parkinson’s disease and related synucleinopathies | 9:00 - 9:30 |
| Ludmilla Morozova-Roche - Linking amyloid and neuroinflammatory cascades in neurodegenerative diseases – role of pro-inflammatory S100A9 protein | 9:30 - 9:50 |
| Salvador Ventura - A novel small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils and prevents degeneration of dopaminergic neurons | 9:50 - 10:10 |
| Georgios Skretas - Engineering bugs for the discovery of new drugs against diseases caused by protein misfolding and aggregation | 10:10 - 10:30 |
| Coffee Break | 10:30 - 11:00 |
| COST NGP-Net action WG4 group meeting – an open discussion on global challenges in field of protein aggregation: what could we do working together? | 11:00 - 12:30 |
| Lunch, Hotel restaurant | 12:30 - 14:00 |
| Session 2, chair: Salvador Ventura | |
| Invited talk - Witold K. Surewicz – Amyloid fibrils from the N-terminal prion protein fragment as a model for studying the mechanism of prion propagation and transmissibility barriers | 14:00 - 14:30 |
| Andrei Kajava - Structural aspects of naturally-occurring amyloids | 14:30 - 14:50 |
| Kristaps Jaudzems - Biomimicry of Artificial Spider Silk Spinning Assessed by NMR Spectroscopy | 14:50 - 15:10 |
| Flash poster presentations (up to 6 presentations up to 3 min. each) | 15:10 - 15:30 |
| Poster Session and Coffee Break | 15:30 - 17:00 |
| Session 3, chair: Sandra Macedo-Ribeiro | |
| Invited talk – Meytal Landau – Extreme Polymorphism in Amyloids from Pathogenic Microbes | 17:00 - 17:30 |
| Gunilla Westermark - Cross-seeding of amyloid as a link between diabetes and Alzheimer’s disease | 17:30 - 17:50 |
| Gil Rosenman - Nanophotonics of Amyloid Peptide Nanostructures | 17:50 - 18:10 |
| Edoardo Salladini - Liquid-liquid phase separation by a viral protein as an additional molecular mechanism of virus-induced cell toxicity | 18:10 - 18:30 |
| Dinner, Rooftop Hotel restaurant | 19:30 - |